Diffusion Cell Apparatus
EMFDC06 – O30
In-vitro skin permeation studies of topical formulations
The Vertical Franz Diffusion Cell is a simple, reproducible test for measuring the in vitro drug release from creams, ointments and gels.
The Franz Cell consists of two primary chambers separated by a membrane. The test product is applied to the membrane via the top chamber- donor compartment. The bottom chamber- receptor compartment contains fluid from which samples are taken at regular intervals for analysis. This testing determines the amount of active drug that has permeated the membrane at each time point.
The Transdermal Diffusion cell apparatus is remarkably simple to operate; the system is supplied with:
- Six stage magnetic stirrer with digital RPM indicator
- Water heater & Water circulation system with digital temperature controller and water level indicator
- Cell holders
- Diffusion Cells
- Teflon coated stirring bars
JFDC07 – O30
In-vitro skin permeation studies of topical formulations
The Vertical Franz Diffusion Cell is a simple, reproducible test for measuring the in vitro drug release from creams, ointments and gels.
The Franz Cell consists of two primary chambers separated by a membrane. The test product is applied to the membrane via the top chamber- donor compartment. The bottom chamber- receptor compartment contains fluid from which samples are taken at regular intervals for analysis. This testing determines the amount of active drug that has permeated the membrane at each time point.
The Transdermal Diffusion cell apparatus is remarkably simple to operate; the system is supplied with:
- Seven stage magnetic stirrer
- Water heater & Water circulation system with water level indicator
- Touch screen control unit for control of speed and temperature
- Cell holders
- Diffusion Cells & accessories pack
Features
- Highly accurate stirring speed and temperature controller
- Precise speed control over stirring range 200-800 rpm using digital speed indicator and controller
- Digital Temperature controller for precise temperature control
- Water Circulation System with water level sensors to avoid damage to heating element
- Magnetics Stirrer with stainless steel body to avoid corrosion
- Sturdy, Heavy duty magnetic Stirrers – allowing continuous & Nonstop Operation
System Specification & Models
| Specification | Model |
| EMFDC06-O30 | |
| Stirrer Drive | |
| Stirrer drive | 6 stage |
| Material of construction of enclosure | S.S. 304 |
| RPM Indicator | Digital |
| RPM Range | 200-800 rpm (±1%) |
| Water circulation System | |
| Material of construction of enclosure | S.S. 304 |
| Temperature range & accuracy | 5°C Above ambient to 60°C (±0.2°C) |
Order Information
| Model | Stirring drive | Certifications | Power requirements | Cells Supplied | Accessories supplied | Optional |
| EMFDC06-O30 | 6 stage | CE Compliant | 220/230V AC 50Hz
110/120V AC 50-60Hz* |
6 Nos cell of 20ml volume | Clamps-6, Aduquate Silicon Tubing, Stirring bar-6 Lid for cell sampling arm-6 Luer Lock Connectors For Cell Interconnections-05Pairs. |
|
Features
- Useful for diffusion cell experiments.
- External temperature sensor probe to determine temperature of media inside the cell.
- Data logging for stirring speed and temperature at sampling interval.
- 10 in built programs.
- Audio/visual alarms for sampling intervals.
- Stirring on/off option prior to sampling.
- Touch screen display.
- Highly accurate stirring speeds and temperature.
- Water Circulation System with water level sensors to avoid damage to heating element.
- Password protected software and admin features.
- Software for data collection & report generation.
- Calibration report generation facility in the software.
- Graphical presentation of data.
- Provision to add experiment Title & comment.
- Data can be converted to excel & Pdf file for further analysis.
System Specification & Models
| Specification | Model |
| JFDC07-O30 | |
| Stirrer Drive | |
| Stirrer drive | 7 stage |
| Material of construction of enclosure | S.S. 304 |
| RPM Indicator | Digital (Touch Screen) |
| RPM Range | 200-800 rpm (±1%) |
| Water circulation System | |
| Material of construction of enclosure | S.S. 304 |
| Inter Cell Temperature Variations | ±1.0°C |
| Inter Cell Stirring Speed Variations | ±1% |
| Temperature range & accuracy | 5°C Above ambient to 60°C (±1.0°C) |
| Temperature Indicator | Digital (Touch Screen) |
Order Information
| Model | Stirring drive | Certifications | Power requirements | Cells Supplied | Accessories supplied | Optional |
| JFDC07-O30 | 7 stage | CE Compliant | 220/230V AC 50Hz 110/120V AC 50-60Hz* |
7 Nos cell of 20ml volume | Clamps-7, Adequate Silicon Tubing for Interconnections, Lid for cell sampling arm-7, Stirring Bars- 7, Dosage Disc and Disc Holders-7 each, Luer Lock Connectors For Cell Interconnections-06pairs, IQ, OQ Documents, RS232 Cord with RS232 to USB convertor-1, software DVD. |
|
Note: Orchid's continuing product development makes specifications subject to change without prior notification.
*Needs to be specified in order information
Diffusion Cell Apparatus :
1. Chauhan, M.K. and Gulati, A., 2016. AGGRANDIZED TRANSDERMAL DELIVERY OF GLIMEPIRIDE VIA TRANSFERSOMES: FORMULATION, EVALUATION AND STATISTICAL OPTIMISATION. Journal of Drug Delivery and Therapeutics, 6(4), pp.48-54.
2. K.Sumalatha*, A.Srinivasa Rao, P.Latha ,2014.DESIGN AND INVITRO EVALUATION OF NANOGE L CONTAINING MENTHA PIPERITA. Sumalatha K et al. / American Journal of Biological and Pharmaceutical Research. 2014;1(3):136-139.
3. Sherafudeen, S.P. and Vasantha, P.V., 2015. Development and evaluation of in situ nasal gel formulations of loratadine. Research in pharmaceutical sciences, 10(6), p.466.
4.Leeladurga, V., Teja, U.C., Sultana, S.A., Sudeep, K., Anusha, V.S.S., Han, T., Nalluri, B.N. and Das, D.B., 2015. Application of Microneedle Arrays for Enhancement of Transdermal Permeation of Insulin: In Vitro Experiments, Scaling Analyses and Numerical Simulations. AAPS PharmSciTech, pp.1-8.
5.Patel, R.B., Vekaria, K.B. and Patel, M.R., 2016. TLC-densitometric method for quantitation of Lurasidone hydrochloride in nanoemulsion, microemulsion, for
equilibrium solubility and ex vivo diffusion studies. Thai Journal of Pharmaceutical Sciences (TJPS), 40(1).
6.Nalluri, B.N., Ram, P.P., Teja, U.C. and Sultana, S.A., 2014. FORMULATION AND EVALUATION OF DRUG IN ADHESIVE TRANSDERMAL PATCHES OF RIVASTIGMINE. Indo American Journal of Pharmaceutical Research, 4(11), pp.5242-5248.
7.Nalluri, B.N., Kosuri, S., Valluru, S.S.A., Uppuluri, C.T. and Sultana, A., Microneedle Assisted Transdermal Delivery of Levodopa. Indian Journal of Pharmaceutical Education and Research | Vol 50 | Issue 2 | Apr-Jun, 2016
8.Arunkumar, S., Ashok, P., Desai, B.G. and Shivakumar, H.N., 2015. Effect of chemical penetration enhancer on transdermal iontophoretic delivery of diclofenac sodium under constant voltage. Journal of Drug Delivery Science and Technology, 30, pp.171-179.
9.Kumbhare, M. and Sivakumar, T., 2011. Anti-inflammatory and antinociceptive activity of pods of Caesalpinia pulcherrima. Journal of Applied Pharmaceutical Science, 1(7), p.18.
10.M.P.SINGH, B.P. NAGORI, N.R. SHAW, R. SOLANKI, M.TIWAR. , 2014. A COMPARISON STUDY OF Q.C. PARAMETERS OF MARKETED TOPICAL GEL FORMULATIONS AND RAJASTHAN GOVT. SUPPLIED FREE TOPICAL GEL FORMULATIONS. INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE. JPRNK ISSN: 2277-8713; Volume 3(1):471-481
11.Jangde, R. and Singh, D., 2016. Preparation and optimization of quercetin-loaded liposomes for wound healing, using response surface methodology. Artificial cells, nanomedicine, and biotechnology, 44(2), pp.635-641.
12.Panchaxari, D.M., Pampana, S., Pal, T., Devabhaktuni, B. and Aravapalli, A.K., 2013. Design and characterization of diclofenac diethylamine transdermal patch using silicone and acrylic adhesives combination. DARU Journal of Pharmaceutical Sciences, 21(1), p.1.