Plethysmometer

For screening of inflammation or oedema in mouse or rat

Orchid’s Digital Plethysmometer is a micro controlled volume meter, specially designed for accurate measurement of the rat / mouse paw swelling.

The Digital Plethysmometer is a highly useful tool to evaluate the inflammatory response experimentally induced in small rodents and to screen potential anti-inflammatory or anti-oedema properties of pharmacological substance. The water displacement produced by the immersion of the animal paw in the measuring tube is reflected in to the second tube, inducing the volume displacement. This displacement value is recorded. The control unit can be zeroed between successive readings by pressing the reset key, so as to avoid the error arising due to adherence of water to the paw of the animal. Foot switch allowing rapid hands-free experiments can be used to control the end point of the measurement.

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200+ Clients Worldwide 50+ Publications

Request Catalog Request Quotation

200+ Clients Worldwide 50+ Publications

Features

Button touch auto-calibration mode making hassle-free calibration
High accuracy : ± 0.01 ml
Resolution: 0.01 ml
Easy-to-use pedal switch
Separate paw immersion tube for rat and mouse
Stable and comfortable reading on the graphical LCD display
The same assembly can be used for rats and mice just by changing the adaptor
Data entry for Experiment Nos./ Sequence Nos./Sex of Animal / Paw: Left - Right etc.
Data storage for 100,000 experiments
Six Point Calibration 0.50ml,1.00ml,2.00ml,3.00ml,4.00ml & 5.00ml.
Software for PC Connectivity using RS232 serial interface for data transfer and report generation with graphical presentation.
No need of separate tube assembly for rat & mice.
Provision to add experiment name, comment & animal weight(grams) in the software report
Data can be transferred to Excel or pdf
Software with password-protected experiment delete function.

Parameters measured:

Mice Paw Volume (0-5ml), Rat Paw Volume (0-10ml)

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System Specification & Models

Specifications	Model
Specifications	PLM 02
Accuracy	± 0.01ml
Resolution	0.01ml
Calibration	Auto and Manual
Display	GLCD
Animals to be tested	Mouse, Rat
PC Connectivity	By Using RS232 Cable
Material of composition	Methacrylate, S.S. 304

Order Information

Model

Certifications

Power requirements

Accessories

PLM 02

CE Compliant

220/230V AC 50Hz

110/120V AC 50-60Hz*

Control unit with communication port to PC & Software utility

Pedal Switch

Immersion tube assembly with reservoir, rat and mouse paw immersion tube and adequate silicon tubing

Retort stand with boss head

Instructional Manual

RS232 Cable and RS232 to USB convertor

Surfactant solution bottle

Calibration probes suitable for: 0.5ml, 1ml, 2ml, 3ml, 4ml, 5ml

Digital pocket conductivity meter

Software for data connectivity

*Needs to be specified in order information

Optional: Computer and printer to be arranged by user

Note: Orchid’s continuing product development makes specifications subject to change without prior notification.

Publications

Digital Plethysmometer :

1. Patel, M.G. and Pundarikakshudu, K., 2016. Effect of ethanol extract of an ayurvedic preparation (Pathyadya Churna) on arthritis in rats. Indian journal of pharmacology, 48(2), p.145.

2. Patel, M.G. and Pundarikakshudu, K., 2015. Anti-arthritic activity of a classical Ayurvedic formulation Vatari Guggulu in rats. Journal of Traditional and Complementary Medicine.

3. Patel, M.G. and Pundarikakshudu, K., 2016. Effect of Shatpuspadya Churna-a classical Ayurvedic formulation on formaldehyde and Complete Freund’s adjuvant (CFA) induced arthritis in rats. Oriental Pharmacy and Experimental Medicine, 16(1), pp.59-65.

4. Singh, R.P. and Narke, R., 2015. PREPARATION AND EVALUATION OF PHYTOSOME OF LAWSONE. International Journal of Pharmaceutical Sciences and Research, 6(12), p.5217.

5. Khan, S.A., Chatterjee, S.S. and Kumar, V., 2016. Low dose aspirin like analgesic and anti- inflammatory activities of mono-hydroxybenzoic acids in stressed rodents. Life sciences, 148, pp.53-62.

6. Patwardhan, S.K. and Bhide, M.A., 2015. EVALUATION OF MYRISTICA FRAGRANS AS A PENETRATION ENHANCER IN TRANSDERMAL GEL FORMULATION. International Journal of Pharmacy and Pharmaceutical Sciences, 7(3), pp.350-355.

7. Kumar, T. and Jain, V., 2014. Antinociceptive and anti-inflammatory activities of Bridelia retusa methanolic fruit extract in experimental animals. The Scientific World Journal, 2014.

8. Khan, J., Alexander, A., Saraf, S. and Saraf, S., 2014. Luteolin–phospholipid complex: preparation, characterization and biological evaluation. Journal of Pharmacy and Pharmacology, 66(10), pp.1451-1462.

9. Rani, P., Pal, D., Hegde, R.R. and Hashim, S.R., 2014. Anticancer, anti-inflammatory, and analgesic activities of synthesized 2-(substituted phenoxy) acetamide derivatives. BioMed research international, 2014.

10. Khobragade, D.S., AK, L.R., Rao, T.K., AVR, P.K., Reddy, G.S. and Potbhare, M.S., 2013. Multi-model confirmatory evaluation of anti-inflammatory, analgesic and

antioxidant activities of Putranjiva roxburghii wall. International Journal of Biomedical and Advance Research, 4(12), pp.921-932.

11. More, S.K., Lande, A.A., Jagdale, P.G., Adkar, P.P. and Ambavade, S.D., 2013. Evaluation of anti-inflammatory activity of Solanum xanthocarpum Schrad and Wendl

(Ka??akari) extract in laboratory animals. Ancient science of life, 32(4), p.222.

12. Kakoti, B.B., Pradhan, P., Borah, S., Mahato, K. and Kumar, M., 2013. Analgesic and anti-inflammatory activities of the methanolic stem bark extract of Nyctanthes arbor- tristis linn. BioMed research international, 2013.

13. SitharaAP, R.M., Mallya, S., Sudhakara, B.S. and Srikanth, P., 2013. Experimental evaluation of analgesic and anti-inflammatory potential of leaves of Anfidesma menasu on wistar albino rats. Int J Pharmacol and Clin Sci, 2, pp.105-12.

14. Naik, S.R., Bhagat, S., Shah, P.D., Tare, A.A., Ingawale, D. and Wadekar, R.R., 2013. Evaluation of anti-allergic and anti-anaphylactic activity of ethanolic extract of Zizyphus jujuba fruits in rodents. Revista Brasileira de Farmacognosia, 23(5), pp.811-818.

COMPARISON WITH OTHER PRODUCTS:

Features	Orchid’s	Other’s
Resolution	0.01ml	0.01ml
Accuracy	±0.01ml	±0.01m
Sensor	Sturdy	Delicate
Auto-Calibration	In-built auto-calibration mode provides user ease of button touch calibration at any time of experiment	Manual Calibration, takes more time
Control on Conductivity of Solution and Reading Stability	Digital pocket conductivity meter is supplied with machine to check conductivity of solution to avoid fluctuations in readings due to conductivity changes in solution	No conductivity meter supplied with machine making variations in the solution prepared leading fluctuations in readings
Immersion Tube Assembly	Easy to clean Teflon stopcocks system Maintenance free as no electronic or electrical components involved	Involves complex solenoid valve assembly with limitations of maintenance
Immersion Tube adaptor	Separate Immersion Tube adaptor For Rat & Mice	Common Immersion Tube adaptor For Rat & Mice